A New Cucurbitacin Glycoside from Kageneckia oblonga (Rosaceae)

A novel cucurbitacin glycoside has been isolated from aerial parts of Kageneckia oblonga R. et P. and shown to be 3β-(β-D-glucosyloxy)-16α,23α-epoxycucurbita-5,24-dien-11-one. The structure was established by usual spectroscopic and two-dimensional (2D ) NMR techniques. This compound has found to be...

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Veröffentlicht in:	Zeitschrift für Naturforschung C. A journal of biosciences 2000-03, Vol.55 (3), p.141-145
Hauptverfasser:	Muñoz, Orlando, Delporte, Carla, Backhouse, Nadine, Erazo, Silvia, Negrete, Rosa, Maldonado, Sergio, López-Pérez, José L., Feliciano, Arturo San
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Cucurbitacin Drug Screening Assays, Antitumor Humans Kageneckia oblonga Mice Plants, Medicinal - chemistry Rosaceae Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Triterpenes Tumor Cells, Cultured
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Zusammenfassung:	A novel cucurbitacin glycoside has been isolated from aerial parts of Kageneckia oblonga R. et P. and shown to be 3β-(β-D-glucosyloxy)-16α,23α-epoxycucurbita-5,24-dien-11-one. The structure was established by usual spectroscopic and two-dimensional (2D ) NMR techniques. This compound has found to be nontoxic when tested in-vivo cell culture assays. In previous investigations we reported 23,24-dihydrocucurbitacin F and prunasine. This was the first report on cucurbitacins from the genus Kageneckia (Rosaceae).
ISSN:	0939-5075 1865-7125
DOI:	10.1515/znc-2000-3-403