Biological evaluation of 2-fluoro-2-[ 123I]Iodo-mannose (FIM): biological evaluation of FIM

This paper describes the biodistribution of a radio-iodinated analog of fluorodeoxyglucose (FDG). 123I-2-fluoro-2-iodo-mannose (FIM) was investigated as a potential single photon emission tomography (SPECT) imaging agent. We also compare the results with the observed distribution of the classical PE...

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Veröffentlicht in:	Nuclear medicine and biology 2001-08, Vol.28 (6), p.679-682
Hauptverfasser:	Matte, G, Adam, M, Lyster, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biodistribution Biological and medical sciences Contrast media. Radiopharmaceuticals Fluoro-deoxy-glucose Fluorodeoxyglucose F18 - pharmacokinetics Glucose metabolites Investigative techniques, diagnostic techniques (general aspects) Iodinated sugar Iodine Radioisotopes Iodomannose Mannose - analogs & derivatives Mannose - pharmacokinetics Medical sciences Mice Miscellaneous. Technology Pharmacology. Drug treatments Radionuclide investigations Radiopharmaceuticals - pharmacokinetics Tissue Distribution
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Beschreibung
Zusammenfassung:	This paper describes the biodistribution of a radio-iodinated analog of fluorodeoxyglucose (FDG). 123I-2-fluoro-2-iodo-mannose (FIM) was investigated as a potential single photon emission tomography (SPECT) imaging agent. We also compare the results with the observed distribution of the classical PET agent 18F-FDG and newly developed 18F-difluorodeoxyglucose (DFDG). Following radioiodination, the final product was stable in-vitro for 24 hrs. Mice showed a rapid blood clearance and deiodination of the 123I-FIM reflected by high stomach and thyroid uptake. Comparison with 18F-FDG and 18F-DFDG revealed a large discrepancy between the 18F labeled sugars and the 123I-FIM biological distribution. The iodinated product was not found to be a metabolic marker for in-vivo studies.
ISSN:	0969-8051 1872-9614
DOI:	10.1016/S0969-8051(01)00236-0