Influence of Ageing on Vasomotor Responses of Human Epicardial Coronary Arteries
: Vasomotor responses to various agonists were studied on isolated circular segments of human epicardial coronary arteries from three different age groups; 23–38 years, 40–58 years and 63–86 years. Noradrenaline had no or only weak contractile effect on coronary arteries from younger patients but in...
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| Veröffentlicht in: | Pharmacology & toxicology 2000-04, Vol.86 (4), p.183-191 |
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| creator | Opgaard, Ole Saetrum Ytterberg2, Hoa T. Saxena, Pramod R. Edvinsson, Lars |
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Vasomotor responses to various agonists were studied on isolated circular segments of human epicardial coronary arteries from three different age groups; 23–38 years, 40–58 years and 63–86 years. Noradrenaline had no or only weak contractile effect on coronary arteries from younger patients but induced contraction of all artery segments from older patients. The Emax value was significantly (P |
| doi_str_mv | 10.1034/j.1600-0773.2000.860406.x |
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Vasomotor responses to various agonists were studied on isolated circular segments of human epicardial coronary arteries from three different age groups; 23–38 years, 40–58 years and 63–86 years. Noradrenaline had no or only weak contractile effect on coronary arteries from younger patients but induced contraction of all artery segments from older patients. The Emax value was significantly (P<0.0001) higher in arteries from the oldest group compared to each of the two younger age groups, whereas the potency was similar in all three groups. Linear regression analysis of noradrenaline‐induced contraction in individual patients revealed a significantly positive age‐correlation (correlation coefficient 0.67, P<0.0001). Contraction induced by endothelin‐1 and relaxation induced by substance P, calcitonin gene‐related peptide and vasoactive intestinal peptide on arteries precontracted with U46619 showed no significant differences in maximum responses and potencies between the three age groups, and no significant linear age‐correlation. These data demonstrate a large variability in contractile responses to noradrenaline with contractions seen mostly in coronary arteries from older patients. It thus seems that sympathetic activation could contribute to coronary ischaemia in some patients.</description><identifier>ISSN: 0901-9928</identifier><identifier>EISSN: 1600-0773</identifier><identifier>DOI: 10.1034/j.1600-0773.2000.860406.x</identifier><identifier>PMID: 10815752</identifier><identifier>CODEN: PHTOEH</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology ; Adult ; Aged ; Aged, 80 and over ; Aging ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Calcitonin Gene-Related Peptide - pharmacology ; Cardiology. Vascular system ; Cardiomyopathies - physiopathology ; Coronary Vessels - drug effects ; Coronary Vessels - physiology ; Coronary Vessels - physiopathology ; Dose-Response Relationship, Drug ; Endothelins - pharmacology ; Humans ; In Vitro Techniques ; Medical sciences ; Middle Aged ; Norepinephrine - pharmacology ; Substance P - pharmacology ; Vasoactive Intestinal Peptide - pharmacology ; Vasoconstriction - drug effects ; Vasoconstrictor Agents - pharmacology ; Vasodilation - drug effects ; Vasomotor System - drug effects ; Vasomotor System - physiology ; Vasomotor System - physiopathology</subject><ispartof>Pharmacology & toxicology, 2000-04, Vol.86 (4), p.183-191</ispartof><rights>2000 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3156-1d501323889f72c00b0bd2ebbe741e7b2c32f077ab6ad39a0299fe0aba53c0ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0773.2000.860406.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0773.2000.860406.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1322565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10815752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Opgaard, Ole Saetrum</creatorcontrib><creatorcontrib>Ytterberg2, Hoa T.</creatorcontrib><creatorcontrib>Saxena, Pramod R.</creatorcontrib><creatorcontrib>Edvinsson, Lars</creatorcontrib><title>Influence of Ageing on Vasomotor Responses of Human Epicardial Coronary Arteries</title><title>Pharmacology & toxicology</title><addtitle>Pharmacol Toxicol</addtitle><description>:
Vasomotor responses to various agonists were studied on isolated circular segments of human epicardial coronary arteries from three different age groups; 23–38 years, 40–58 years and 63–86 years. Noradrenaline had no or only weak contractile effect on coronary arteries from younger patients but induced contraction of all artery segments from older patients. The Emax value was significantly (P<0.0001) higher in arteries from the oldest group compared to each of the two younger age groups, whereas the potency was similar in all three groups. Linear regression analysis of noradrenaline‐induced contraction in individual patients revealed a significantly positive age‐correlation (correlation coefficient 0.67, P<0.0001). Contraction induced by endothelin‐1 and relaxation induced by substance P, calcitonin gene‐related peptide and vasoactive intestinal peptide on arteries precontracted with U46619 showed no significant differences in maximum responses and potencies between the three age groups, and no significant linear age‐correlation. These data demonstrate a large variability in contractile responses to noradrenaline with contractions seen mostly in coronary arteries from older patients. It thus seems that sympathetic activation could contribute to coronary ischaemia in some patients.</description><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Calcitonin Gene-Related Peptide - pharmacology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - physiology</subject><subject>Coronary Vessels - physiopathology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelins - pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Norepinephrine - pharmacology</subject><subject>Substance P - pharmacology</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilation - drug effects</subject><subject>Vasomotor System - drug effects</subject><subject>Vasomotor System - physiology</subject><subject>Vasomotor System - physiopathology</subject><issn>0901-9928</issn><issn>1600-0773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLxDAQgIMouuj-Bakg3lonSZ_HdfEFgiKr15CkU4m0yZpscf33tnRRj56GzHyTmfkIOaOQUODp5XtCc4AYioInDACSMocU8mS7R2Y_lX0ygwpoXFWsPCLzEIwCnhUlpWl-SI4olDQrMjYjT_e2aXu0GiPXRIs3NPYtcjZ6lcF1buN89Ixh7WzAMAJ3fSdtdL02WvrayDZaOu-s9F_Rwm_QGwwn5KCRbcD5Lh6Tl5vr1fIufni8vV8uHmLNaZbHtM6AcsbLsmoKpgEUqJqhUlikFAvFNGfNcIlUuax5JYFVVYMglcy4hiF1TC6mf9feffQYNqIzQWPbSouuD6KglOaMpwNYTaD2LgSPjVh70w0rCwpiNCrexehNjN7EaFRMRsV26D3dDelVh_WfzsnfAJzvABm0bBsvrTbhl-OMZXk2YIsJ-zQtfv1_AXG1fFpND_4NKe6RyQ</recordid><startdate>200004</startdate><enddate>200004</enddate><creator>Opgaard, Ole Saetrum</creator><creator>Ytterberg2, Hoa T.</creator><creator>Saxena, Pramod R.</creator><creator>Edvinsson, Lars</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200004</creationdate><title>Influence of Ageing on Vasomotor Responses of Human Epicardial Coronary Arteries</title><author>Opgaard, Ole Saetrum ; Ytterberg2, Hoa T. ; Saxena, Pramod R. ; Edvinsson, Lars</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3156-1d501323889f72c00b0bd2ebbe741e7b2c32f077ab6ad39a0299fe0aba53c0ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Calcitonin Gene-Related Peptide - pharmacology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - physiology</topic><topic>Coronary Vessels - physiopathology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelins - pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Norepinephrine - pharmacology</topic><topic>Substance P - pharmacology</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilation - drug effects</topic><topic>Vasomotor System - drug effects</topic><topic>Vasomotor System - physiology</topic><topic>Vasomotor System - physiopathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Opgaard, Ole Saetrum</creatorcontrib><creatorcontrib>Ytterberg2, Hoa T.</creatorcontrib><creatorcontrib>Saxena, Pramod R.</creatorcontrib><creatorcontrib>Edvinsson, Lars</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Opgaard, Ole Saetrum</au><au>Ytterberg2, Hoa T.</au><au>Saxena, Pramod R.</au><au>Edvinsson, Lars</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Ageing on Vasomotor Responses of Human Epicardial Coronary Arteries</atitle><jtitle>Pharmacology & toxicology</jtitle><addtitle>Pharmacol Toxicol</addtitle><date>2000-04</date><risdate>2000</risdate><volume>86</volume><issue>4</issue><spage>183</spage><epage>191</epage><pages>183-191</pages><issn>0901-9928</issn><eissn>1600-0773</eissn><coden>PHTOEH</coden><abstract>:
Vasomotor responses to various agonists were studied on isolated circular segments of human epicardial coronary arteries from three different age groups; 23–38 years, 40–58 years and 63–86 years. Noradrenaline had no or only weak contractile effect on coronary arteries from younger patients but induced contraction of all artery segments from older patients. The Emax value was significantly (P<0.0001) higher in arteries from the oldest group compared to each of the two younger age groups, whereas the potency was similar in all three groups. Linear regression analysis of noradrenaline‐induced contraction in individual patients revealed a significantly positive age‐correlation (correlation coefficient 0.67, P<0.0001). Contraction induced by endothelin‐1 and relaxation induced by substance P, calcitonin gene‐related peptide and vasoactive intestinal peptide on arteries precontracted with U46619 showed no significant differences in maximum responses and potencies between the three age groups, and no significant linear age‐correlation. These data demonstrate a large variability in contractile responses to noradrenaline with contractions seen mostly in coronary arteries from older patients. It thus seems that sympathetic activation could contribute to coronary ischaemia in some patients.</abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>10815752</pmid><doi>10.1034/j.1600-0773.2000.860406.x</doi><tpages>9</tpages></addata></record> |
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| subjects | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Adult Aged Aged, 80 and over Aging Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Calcitonin Gene-Related Peptide - pharmacology Cardiology. Vascular system Cardiomyopathies - physiopathology Coronary Vessels - drug effects Coronary Vessels - physiology Coronary Vessels - physiopathology Dose-Response Relationship, Drug Endothelins - pharmacology Humans In Vitro Techniques Medical sciences Middle Aged Norepinephrine - pharmacology Substance P - pharmacology Vasoactive Intestinal Peptide - pharmacology Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasomotor System - drug effects Vasomotor System - physiology Vasomotor System - physiopathology |
| title | Influence of Ageing on Vasomotor Responses of Human Epicardial Coronary Arteries |
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