Influence of Ageing on Vasomotor Responses of Human Epicardial Coronary Arteries

: Vasomotor responses to various agonists were studied on isolated circular segments of human epicardial coronary arteries from three different age groups; 23–38 years, 40–58 years and 63–86 years. Noradrenaline had no or only weak contractile effect on coronary arteries from younger patients but in...

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Veröffentlicht in:	Pharmacology & toxicology 2000-04, Vol.86 (4), p.183-191
Hauptverfasser:	Opgaard, Ole Saetrum, Ytterberg2, Hoa T., Saxena, Pramod R., Edvinsson, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Adult Aged Aged, 80 and over Aging Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Calcitonin Gene-Related Peptide - pharmacology Cardiology. Vascular system Cardiomyopathies - physiopathology Coronary Vessels - drug effects Coronary Vessels - physiology Coronary Vessels - physiopathology Dose-Response Relationship, Drug Endothelins - pharmacology Humans In Vitro Techniques Medical sciences Middle Aged Norepinephrine - pharmacology Substance P - pharmacology Vasoactive Intestinal Peptide - pharmacology Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasomotor System - drug effects Vasomotor System - physiology Vasomotor System - physiopathology
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Zusammenfassung:	: Vasomotor responses to various agonists were studied on isolated circular segments of human epicardial coronary arteries from three different age groups; 23–38 years, 40–58 years and 63–86 years. Noradrenaline had no or only weak contractile effect on coronary arteries from younger patients but induced contraction of all artery segments from older patients. The Emax value was significantly (P
ISSN:	0901-9928 1600-0773
DOI:	10.1034/j.1600-0773.2000.860406.x