Wnt signalling: Antagonistic Dickkopfs

Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt–Frizzled–LRP5/6 receptor complexes, thus blocking the canonical Wnt–β-catenin pathway.

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Bibliographische Detailangaben
Veröffentlicht in:	Current biology 2001-08, Vol.11 (15), p.R592-R595
1. Verfasser:	Zorn, Aaron M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Frizzled Receptors Humans Intercellular Signaling Peptides and Proteins LDL-Receptor Related Proteins Low Density Lipoprotein Receptor-Related Protein-5 Protein Binding Proteins - antagonists & inhibitors Proteins - metabolism Proteins - physiology Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Receptors, LDL - antagonists & inhibitors Receptors, LDL - metabolism Signal Transduction Wnt Proteins Zebrafish Proteins
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Beschreibung
Zusammenfassung:	Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt–Frizzled–LRP5/6 receptor complexes, thus blocking the canonical Wnt–β-catenin pathway.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(01)00360-8