REST Acts through Multiple Deacetylase Complexes

The RE1 binding silencer protein REST represses neuronal-specific gene expression in nonneuronal cell types. In this issue of Neuron, Ballas et al. show that REST inhibits gene expression via the recruitment of multiple histone deacetylase complexes.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuron 2001-08, Vol.31 (3), p.339-340
Hauptverfasser:	Griffith, Eric C., Cowan, Christopher W., Greenberg, Michael E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - metabolism Animals DNA-Binding Proteins - metabolism Gene Silencing Neurons - physiology Promoter Regions, Genetic Repressor Proteins - metabolism Spinal Cord - physiology Transcription Factors - metabolism Transcription, Genetic Zinc Fingers
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The RE1 binding silencer protein REST represses neuronal-specific gene expression in nonneuronal cell types. In this issue of Neuron, Ballas et al. show that REST inhibits gene expression via the recruitment of multiple histone deacetylase complexes.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/S0896-6273(01)00386-5