Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-Proteinase: solid-Phase synthesis of ornithine analogues

A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP). A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-08, Vol.11 (16), p.2085-2088
Hauptverfasser:	Dankwardt, Sharon M., Martin, Robert L., Chan, Christine S., Van Wart, Harold E., Walker, Keith A.M., Delaet, Nancy G., Robinson, Leslie A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Biological and medical sciences Bone Morphogenetic Protein 1 Bone Morphogenetic Proteins - antagonists & inhibitors Bone Morphogenetic Proteins - metabolism Bones, joints and connective tissue. Antiinflammatory agents Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Medical sciences Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - metabolism Ornithine - analogs & derivatives Ornithine - chemical synthesis Ornithine - chemistry Ornithine - pharmacology Pharmacology. Drug treatments Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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Zusammenfassung:	A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP). A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00384-5