Detection of B Virus Infection in Cynomolgus Monkeys by ELISA Using Simian Agent 8 as Alternative Antigen

The use of simian agent 8 (SA8) as an antigen for B virus (BV) antibody detection was evaluated in cynomolgus monkeys. Seventy-two sera judged as positive using BV antigen were all positive when the SA8 antigen was used. Out of 28 BV-negative sera 2 were positive against the SA8 antigen and one seru...

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Veröffentlicht in:	Experimental Animals 2001, Vol.50(4), pp.345-347
Hauptverfasser:	TAKANO, Jun-ichiro, NARITA, Toyoko, FUJIMOTO, Koji, MUKAI, Ryozaburo, YAMADA, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - analysis Antigens, Viral - analysis B virus ELISA Enzyme-Linked Immunosorbent Assay - veterinary False Negative Reactions Herpesviridae - immunology Herpesviridae Infections - diagnosis Herpesviridae Infections - immunology Herpesviridae Infections - veterinary Herpesvirus 1, Cercopithecine - immunology Macaca fascicularis - virology SA8 Sensitivity and Specificity simian agent 8
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Zusammenfassung:	The use of simian agent 8 (SA8) as an antigen for B virus (BV) antibody detection was evaluated in cynomolgus monkeys. Seventy-two sera judged as positive using BV antigen were all positive when the SA8 antigen was used. Out of 28 BV-negative sera 2 were positive against the SA8 antigen and one serum was classified as indeterminate. The present data indicates that detection of BV antibody can be achieved accurately and safely by enzyme-linked immunosorbent assay (ELISA) using SA8 antigen.
ISSN:	1341-1357 1881-7122
DOI:	10.1538/expanim.50.345