Negative Inotropic and Chronotropic Effects of Oxytocin

ABSTRACT—We have previously shown that oxytocin receptors are present in the heart and that perfusion of isolated rat hearts with oxytocin results in decreased cardiac flow rate and bradycardia. The mechanisms involved in the negative inotropic and chronotropic effects of oxytocin were investigated...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-08, Vol.38 (2), p.292-296
Hauptverfasser:	Mukaddam-Daher, Suhayla, Yin, Ya-Lin, Roy, Josée, Gutkowska, Jolanta, Cardinal, René
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Biological and medical sciences Culture Techniques Depression, Chemical Dogs Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Heart Atria - drug effects Heart Rate - drug effects Hemodynamics. Rheology Hormone Antagonists - pharmacology Male Myocardial Contraction - drug effects NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Oxytocin - analogs & derivatives Oxytocin - pharmacology Parasympatholytics - pharmacology Vertebrates: cardiovascular system
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Zusammenfassung:	ABSTRACT—We have previously shown that oxytocin receptors are present in the heart and that perfusion of isolated rat hearts with oxytocin results in decreased cardiac flow rate and bradycardia. The mechanisms involved in the negative inotropic and chronotropic effects of oxytocin were investigated in isolated dog right atria in the absence of central mechanisms. Perfusion of atria through the sinus node artery with 10 mol/L oxytocin over 5 minutes (8 mL/min) significantly decreased both beating rate (−14.7±4.9% of basal levels, n=5, P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.hyp.38.2.292