Estrogenic Activity of Phenolic Compounds from Nigella damascena Evaluated Using a Recombinant Yeast Screen

Abstract We used a yeast estrogen screen (YES) containing human estrogen receptor to evaluate the estrogenic activity of both crude extracts and simple pure phenolic compounds from NIGELLA DAMASCENA seeds. Estrogenic activity was established in the methanolic and aqueous extracts of the seeds as wel...

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Veröffentlicht in:	Planta medica 2001-08, Vol.67 (6), p.553-555
Hauptverfasser:	Agradi, Elisabetta, Fico, Gelsomina, Cillo, Fabiana, Francisci, Chiara, Tomè, Franca
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Colony-Stimulating Factors - drug effects Estrogens - chemistry Estrogens - isolation & purification Estrogens - pharmacology General pharmacology Humans Lac Operon Letter Magnoliopsida - chemistry Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenylacetates - chemistry Phenylacetates - isolation & purification Phenylacetates - pharmacology Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - chemistry Phenylethyl Alcohol - isolation & purification Phenylethyl Alcohol - pharmacology Plant Extracts - pharmacology Plants, Medicinal - chemistry Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Proteins Saccharomyces cerevisiae
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Zusammenfassung:	Abstract We used a yeast estrogen screen (YES) containing human estrogen receptor to evaluate the estrogenic activity of both crude extracts and simple pure phenolic compounds from NIGELLA DAMASCENA seeds. Estrogenic activity was established in the methanolic and aqueous extracts of the seeds as well as in two simple phenolic compounds isolated from the methanolic extract, 2,4-dihydroxyphenylacetic acid, 3,4-dihydroxy-β-phenethyl alcohol.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2001-16485