Cross-talk between nitric oxide and HSP70 in the antihypotensive effect of adaptation to heat

Cross-talk between nitric oxide and HSP70 in the antihypotensive effect of adaptation to heat

In this work, we evaluated the effect of adaptation to heat on the fall of blood pressure (BP) induced by heat shock (HS) and the interrelation between nitric oxide (NO) and heat shock protein, HSP70. Experiments were carried out on Wistar rats. It was shown that HS resulted in a generalized and tra...

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Veröffentlicht in:Physiological research 2000, Vol.49 (1), p.99-105
Hauptverfasser: Malyshev IYu, Bayda, L A, Trifonov, A I, Larionov, N P, Kubrina, L D, Mikoyan, V D, Vanin, A F, Manukhina, E B
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Physiological
Animals
Blood Pressure
Enzyme Inhibitors - pharmacology
Hot Temperature
HSP70 Heat-Shock Proteins - biosynthesis
Hypotension - etiology
Male
Nitric Oxide - biosynthesis
Nitric Oxide Synthase - antagonists & inhibitors
Nitroarginine - pharmacology
Quercetin - pharmacology
Rats
Rats, Wistar
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Zusammenfassung:In this work, we evaluated the effect of adaptation to heat on the fall of blood pressure (BP) induced by heat shock (HS) and the interrelation between nitric oxide (NO) and heat shock protein, HSP70. Experiments were carried out on Wistar rats. It was shown that HS resulted in a generalized and transient increase in NO production (the electron paramagnetic resonance method) and a fall of BP from 113+/-3 to 88+/-1 mm Hg (p
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.930000.49.99