Detection of high-risk HPV types by the hybrid capture 2 test

A hybrid capture test that can be used to detect at least 13 high‐risk HPV types (referred to collectively as HPV‐HR) in cervical scrapes (Hybrid Capture 2 probe set B, HC2‐B) was evaluated. The HC2‐B test is accurate and highly reproducible and the results obtained show excellent agreement with tho...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of medical virology 2001-09, Vol.65 (1), p.155-162
Hauptverfasser: Terry, George, Ho, Linda, Londesborough, Philip, Cuzick, Jack, Mielzynska-Lohnas, Iwona, Lorincz, Attila
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A hybrid capture test that can be used to detect at least 13 high‐risk HPV types (referred to collectively as HPV‐HR) in cervical scrapes (Hybrid Capture 2 probe set B, HC2‐B) was evaluated. The HC2‐B test is accurate and highly reproducible and the results obtained show excellent agreement with those obtained by a multiplexed type‐specific polymerase chain reaction (mts‐PCR). An additional assay to identify a subset of HPV‐HR types may improve specificity without compromising sensitivity in HC2‐B positive specimens with a test result close to the cut‐off value given by 1 pg/ml HPV DNA. J. Med. Virol. 65:155–162, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.2015