A Model of Synaptic Memory: A CaMKII/PP1 Switch that Potentiates Transmission by Organizing an AMPA Receptor Anchoring Assembly

Ca 2+/calmodulin-dependent protein kinase II (CaMKII) is localized in the postsynaptic density (PSD) and is necessary for LTP induction. Much has been learned about the autophosphorylation of CaMKII and its dephosphorylation by PSD protein phosphatase-1 (PP1). Here, we show how the CaMKII/PP1 system...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2001-08, Vol.31 (2), p.191-201
Hauptverfasser:	Lisman, John E, Zhabotinsky, Anatol M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism Humans Long-Term Potentiation Mathematics Models, Neurological Phosphoprotein Phosphatases - metabolism Phosphorylation postsynaptic density Protein Phosphatase 1 Receptors, AMPA - physiology Synapses - physiology Synaptic Transmission - physiology
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