Intragraft localization of activated nuclear factor kappaB in recurrent hepatitis C virus disease following liver transplantation

Intragraft localization of activated nuclear factor kappaB in recurrent hepatitis C virus disease following liver transplantation

Nuclear factor kappaB (NF-kappaB) is activated during viral infection and is central to the regulation of host immune responses. The NF-kappaB activation status and its morphological sources were assessed by immunohistochemistry in allograft biopsy specimens of orthotopic liver transplantation patie...

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Veröffentlicht in:Hepatology (Baltimore, Md.) Md.), 2000-05, Vol.31 (5), p.1183-1191
Hauptverfasser: Gaweco, A S, Wiesner, R H, Porayko, M, Rustgi, V K, Yong, S, Hamdani, R, Harig, J, Chejfec, G, McClatchey, K D, Van Thiel, D H
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Cyclosporine - pharmacology
Dimerization
Female
Hepatitis C - immunology
Hepatitis C - pathology
Hepatitis C - virology
Humans
Immunohistochemistry
Liver Transplantation - adverse effects
Male
Middle Aged
NF-kappa B - analysis
NF-kappa B - chemistry
NF-kappa B - metabolism
Recurrence
RNA, Viral - analysis
Tacrolimus - pharmacology
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Zusammenfassung:Nuclear factor kappaB (NF-kappaB) is activated during viral infection and is central to the regulation of host immune responses. The NF-kappaB activation status and its morphological sources were assessed by immunohistochemistry in allograft biopsy specimens of orthotopic liver transplantation patients with recurrent hepatitis C virus (HCV). Hepatocellular NF-kappaB immunostaining was detected in HCV cases compared with controls (nontransplant: P
ISSN:0270-9139