Adapter proteins in lymphocyte antigen-receptor signaling

Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte developm...

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Veröffentlicht in:	Current Opinion in Immunology 2000-06, Vol.12 (3), p.256-266
Hauptverfasser:	Myung, Peggy S, Boerthe, Nancy J, Koretzky, Gary A
Format:	Artikel
Sprache:	eng
Schlagworte:	AB-cell receptor Adapter proteins B cell receptor Lymphocyte antigen receptor signaling Lymphocytes - immunology Models, Immunological Proteins - metabolism Receptors, Antigen - metabolism Receptors, Antigen, B-Cell - metabolism Receptors, Antigen, T-Cell - metabolism Signal Transduction T cell receptor
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Beschreibung
Zusammenfassung:	Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte development and function.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/S0952-7915(00)00085-6