Successful treatment of cervical and simultaneous cervico-isthmic pregnancy with methotrexate

To describe the monitoring of a case of cervical and simultaneous cervico-isthmic pregnancy. University of Bari (Italy), Department of Obstetrics and Gynecology. A 30-year-old white woman, nulliparous, at 8 weeks of amenorrhoea. Methotrexate and folinic acid administered systemically. Treatment success was defined as elimination of the cervical and cervico-isthmic pregnancy, with non-invasive treatment and preservation of the uterus and normal ovarian activity restored. Methotrexate and folinic acid were administered, elimination of a twin pregnancy with declining serum beta-hCG levels and with ultrasound was observed. The patient had only occasional dark vaginal bleeding and temporary movement of the transaminase. This case report shows that methotrexate is a valid, conservative and non-invasive treatment for a patient affected by cervical pregnancy who wishes to keep fertility.