Immune response to infection with Salmonella typhimurium in mice

Infection of mice with Salmonella typhimurium results in systemic infection and a disease similar to that seen in humans after infection with S. typhi. The innate immune system can restrict replication of S. typhimurium to a certain degree, but for effective control and eradication of bacteria, acqu...

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Veröffentlicht in:Journal of leukocyte biology 2000-04, Vol.67 (4), p.457-463
Hauptverfasser: Mittrücker, Hans-Willi, Kaufmann, Stefan H E
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Sprache:eng
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Zusammenfassung:Infection of mice with Salmonella typhimurium results in systemic infection and a disease similar to that seen in humans after infection with S. typhi. The innate immune system can restrict replication of S. typhimurium to a certain degree, but for effective control and eradication of bacteria, acquired immunity is essential. Salmonella infection induces the generation of specific CD4+ and CD8+ T cells, and both T cell populations are important for protection during primary and secondary responses, although the mechanisms underlying T cell‐mediated protection are not yet completely understood. Infection with S. typhimurium also results in a strong antibody response to Salmonella antigens and, in contrast to most other intracellular bacteria, this antibody response participates in protection. In summary, the response to S. typhimurium involves both T and B cell‐mediated immunity, and mechanisms mediated by both lymphocyte populations are important for control of primary infection and protection against secondary infection. J. Leukoc. Biol. 67: 457–463; 2000.
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.67.4.457