Design, Synthesis, and Structure−Activity Relationships of a Series of 3-[2-(1-Benzylpiperidin-4-yl)ethylamino]pyridazine Derivatives as Acetylcholinesterase Inhibitors

Starting from the 3-[2-(1-benzylpiperidin-4-yl)ethylamino]-6-phenylpyridazine 1, we performed the design, the synthesis, and the structure−activity relationships of a series of pyridazine analogues acting as AChE inhibitors. Structural modifications were achieved on four different parts of compound...

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Veröffentlicht in:Journal of medicinal chemistry 2001-08, Vol.44 (17), p.2707-2718
Hauptverfasser: Contreras, Jean-Marie, Parrot, Isabelle, Sippl, Wolfgang, Rival, Yveline M, Wermuth, Camille G
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Sprache:eng
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