Plasmodium telomeres: a pathogen's perspective

New data on the organization of plasmodial telomeres has recently become available. Telomeres form clusters of four to seven heterologous chromosome ends at the nuclear periphery in asexual and sexual parasite stages. This subnuclear compartment promotes gene conversion between members of subtelomer...

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Veröffentlicht in:	Current Opinion in Microbiology 2001-08, Vol.4 (4), p.409-414
Hauptverfasser:	Scherf, Artur, Figueiredo, Luisa M, Freitas-Junior, Lúcio H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences chromatin ectopic recombination epigenetic regulation Fundamental and applied biological sciences. Psychology Gene Expression Regulation Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - parasitology Medical sciences Microbiology nuclear architecture Parasitic diseases Plasmodium Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Plasmodium falciparum - pathogenicity Protozoa Protozoal diseases subtelomeric region telomerase Telomere - genetics telomeres Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virulence - genetics
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Zusammenfassung:	New data on the organization of plasmodial telomeres has recently become available. Telomeres form clusters of four to seven heterologous chromosome ends at the nuclear periphery in asexual and sexual parasite stages. This subnuclear compartment promotes gene conversion between members of subtelomeric virulence factor genes in heterologous chromosomes resulting in diversity of antigenic and adhesive phenotypes. This has important implications for parasite survival.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/S1369-5274(00)00227-7