β-adrenergic blockade in developing heart failure: Effects on myocardial inflammatory cytokines, nitric oxide, and remodeling

Whether beta-adrenergic blockade modulates myocardial expression of inflammatory cytokines and nitric oxide (NO) in heart failure is unclear. We administered oral metoprolol or no therapy to rats for 12 weeks after large myocardial infarction and subsequently examined left ventricular (LV) remodelin...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-05, Vol.101 (17), p.2103-2109
Hauptverfasser:	PRABHU, S. D, CHANDRASEKAR, B, MURRAY, D. R, FREEMAN, G. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Biological and medical sciences Cardiovascular system Cytokines - metabolism Gene Expression Interleukin-1 - metabolism Interleukin-6 - metabolism Isoproterenol - pharmacology Medical sciences Metoprolol - pharmacology Miscellaneous Myocardial Infarction - drug therapy Myocardial Infarction - immunology Myocardial Infarction - physiopathology Myocardium - immunology Myocardium - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Pharmacology. Drug treatments Rats Rats, Inbred WKY Tumor Necrosis Factor-alpha - metabolism Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - immunology Ventricular Dysfunction, Left - metabolism Ventricular Remodeling - drug effects
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Zusammenfassung:	Whether beta-adrenergic blockade modulates myocardial expression of inflammatory cytokines and nitric oxide (NO) in heart failure is unclear. We administered oral metoprolol or no therapy to rats for 12 weeks after large myocardial infarction and subsequently examined left ventricular (LV) remodeling; myocardial tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 expression; and NO. In untreated rats, echocardiography revealed significant (P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.101.17.2103