4-Thiazolidinones: Novel inhibitors of the bacterial enzyme MurB

4-Thiazolidinones: Novel inhibitors of the bacterial enzyme MurB

4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2000-04, Vol.10 (8), p.715-717
Hauptverfasser: ANDRES, C. J, BRONSON, A. J. J, STOCK, D, YAXIONG SUN, WALSH, A. W, D'ANDREA, A. S. V, DESHPANDE, A. M. S, FALK, P. J, GRANT-YOUNG, K. A, HARTE, W. E, HO, H.-T, MISCO, P. F, ROBERTSON, J. G
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - enzymology
Biological and medical sciences
Carbohydrate Dehydrogenases - antagonists & inhibitors
Enzyme Inhibitors - pharmacology
Medical sciences
Pharmacology. Drug treatments
Thiazoles - pharmacology
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Zusammenfassung:4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00073-1