Pantoprazole 20 mg is an effective maintenance therapy for patients with gastro-oesophageal reflux disease

OBJECTIVES STUDY DESIGNPatients (18-84 years old; n = 433) with healed GORD II or III were included in this prospective multi-centre, randomized, parallel, double-blind study. Pantoprazole was administered once daily for up to 1 year as either a 20 mg or 40 mg enteric-coated tablet to 221 and 212 pa...

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Veröffentlicht in:European journal of gastroenterology & hepatology 2000-04, Vol.12 (4), p.425-432
Hauptverfasser: Plein, K, Hotz, J, Wurzer, H, Fumagalli, I, Lühmann, R, Schneider, A
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Sprache:eng
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Zusammenfassung:OBJECTIVES STUDY DESIGNPatients (18-84 years old; n = 433) with healed GORD II or III were included in this prospective multi-centre, randomized, parallel, double-blind study. Pantoprazole was administered once daily for up to 1 year as either a 20 mg or 40 mg enteric-coated tablet to 221 and 212 patients, respectively. Symptoms of GORD were assessed every 3 months. Endoscopy was performed at entry, after 6 and 12 months, or when symptoms of GORD were perceived on at least three consecutive days. The primary efficacy parameter was the time until endoscopically proven relapse of GORD occurred (stage I or greater); the secondary parameters included tolerability, safety, and time until symptomatic relapse occurred. RESULTS CONCLUSIONSBoth the 20 mg and 40 mg doses of pantoprazole are safe and effective in maintaining patients with healed reflux oesophagitis in remission. Moreover, for the majority of patients, the 20 mg dose provides adequate long-term therapeutic efficacy at a minimal drug exposure and lower costs. Eur J Gastroenterol Hepatol 12:425-432 © 2000 Lippincott Williams & WilkinsEuropean Journal of Gastroenterology & Hepatology 2000, 12:425-432
ISSN:0954-691X
1473-5687
DOI:10.1097/00042737-200012040-00010