Inhibition of Cyclooxygenase-2 Expression by Diarylheptanoids from the Bark of Alnus hirsuta var. sibirica
Two known diarylheptanoids, oregonin (1), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-xylopyranoside and hirsutanonol (2), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-t...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2000/04/01, Vol.23(4), pp.517-518 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | LEE, Min-Won KIM, Jung-Hwan JEONG, Dong-Wook AHN, Kyoung-Hwan TOH, Sang-Hak SURH, Young-Joon |
| description | Two known diarylheptanoids, oregonin (1), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-xylopyranoside and hirsutanonol (2), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCDF10A cells. |
| doi_str_mv | 10.1248/bpb.23.517 |
| format | Article |
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Homeopathy. Health food</subject><subject>Pharmacology. 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| subjects | Alnus hirsuta var. sibirica Biological and medical sciences Cell Line, Transformed Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology cyclooxygenase-2 inhibitor diarylheptanoid Diarylheptanoids General pharmacology Glycosides - pharmacology Humans Isoenzymes - pharmacology Medical sciences Membrane Proteins Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Prostaglandin-Endoperoxide Synthases - pharmacology Terpenes - pharmacology Trees - chemistry |
| title | Inhibition of Cyclooxygenase-2 Expression by Diarylheptanoids from the Bark of Alnus hirsuta var. sibirica |
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