Inhibition of Cyclooxygenase-2 Expression by Diarylheptanoids from the Bark of Alnus hirsuta var. sibirica

Two known diarylheptanoids, oregonin (1), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-xylopyranoside and hirsutanonol (2), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-t...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2000/04/01, Vol.23(4), pp.517-518
Hauptverfasser:	LEE, Min-Won, KIM, Jung-Hwan, JEONG, Dong-Wook, AHN, Kyoung-Hwan, TOH, Sang-Hak, SURH, Young-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alnus hirsuta var. sibirica Biological and medical sciences Cell Line, Transformed Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology cyclooxygenase-2 inhibitor diarylheptanoid Diarylheptanoids General pharmacology Glycosides - pharmacology Humans Isoenzymes - pharmacology Medical sciences Membrane Proteins Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Prostaglandin-Endoperoxide Synthases - pharmacology Terpenes - pharmacology Trees - chemistry
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Zusammenfassung:	Two known diarylheptanoids, oregonin (1), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-xylopyranoside and hirsutanonol (2), (5S)-1, 7-bis-(3, 4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCDF10A cells.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.23.517