The design of antiparallel coiled coils

Recent structural studies have highlighted the importance of antiparallel coiled coils in nature. In addition, well-behaved, model antiparallel coiled coils have been designed and used for the reassembly of protein fragments and for the study of the energetic contributions of various interactions to...

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Veröffentlicht in:	Current Opinion in Structural Biology 2001-08, Vol.11 (4), p.450-457
Hauptverfasser:	Oakley, Martha G, Hollenbeck, Jessica J
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Bacterial Proteins - chemistry Coiled coils Databases, Factual fibrous proteins Forecasting helical bundle Hepatitis Antigens - chemistry Hepatitis delta Antigens Humans Models, Molecular Protein Conformation protein design Protein Kinase C Protein Structure, Secondary Protein-Serine-Threonine Kinases - chemistry Protein-Tyrosine Kinases - chemistry relative helix orientation RNA-Binding Proteins - chemistry Serine-tRNA Ligase - chemistry Spectrin - chemistry
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Beschreibung
Zusammenfassung:	Recent structural studies have highlighted the importance of antiparallel coiled coils in nature. In addition, well-behaved, model antiparallel coiled coils have been designed and used for the reassembly of protein fragments and for the study of the energetic contributions of various interactions to helix orientation specificity. Finally, high-resolution structural data are available for designed helical bundles, allowing an evaluation of the success of state-of-the-art protein design efforts.
ISSN:	0959-440X 1879-033X
DOI:	10.1016/S0959-440X(00)00232-3