Cytotoxic Prenylxanthones from Garcinia bracteata

Bioassay-guided fractionation of a leaf extract of G. bracteata has yielded six new prenylxanthones, bractatin (1), isobractatin (2), 1-O-methylbractatin (3), 1-O-methylisobractatin (4), 1-O-methyl-8-methoxy-8,8a-dihydrobractatin (5), and 1-O-methylneobractatin (6). The structures of these compounds...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-04, Vol.63 (4), p.441-446
Hauptverfasser:	Thoison, Odile, Fahy, Jacques, Dumontet, Vincent, Chiaroni, Angèle, Riche, Claude, Tri, Mai Van, Sévenet, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	1-o-methyl-8-methoxy-8,8a-dihydrobractatin 1-o-methylbractatin 1-o-methylisobractatin 1-o-methylneobractatin Alkyl and Aryl Transferases - antagonists & inhibitors Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences bractatin cell lines chemical constituents of plants chemical structure Crystallography, X-Ray cytotoxic compounds Enzyme Inhibitors - pharmacology Garcinia General pharmacology Humans isobractatin kb cell lines KB Cells leaves Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences medicinal properties Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry spectral analysis Spectrophotometry, Ultraviolet Xanthenes - isolation & purification Xanthenes - pharmacology xanthones
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Zusammenfassung:	Bioassay-guided fractionation of a leaf extract of G. bracteata has yielded six new prenylxanthones, bractatin (1), isobractatin (2), 1-O-methylbractatin (3), 1-O-methylisobractatin (4), 1-O-methyl-8-methoxy-8,8a-dihydrobractatin (5), and 1-O-methylneobractatin (6). The structures of these compounds have been elucidated by spectroscopic means (NMR, MS), literature data, and X-ray crystallographic analysis of 2. These compounds possess significant cytotoxicity against the KB cell line.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9903088