Inhibition of DNA Topoisomerases by Nidulalin A Derivatives
Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F380B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 μM and 16 μM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2000/04/01, Vol.23(4), pp.511-512 |
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| container_title | Biological & pharmaceutical bulletin |
| container_volume | 23 |
| creator | SATO, Seiichi FUKUDA, Yumiko NAKAGAWA, Ryusuke TSUJI, Takashi UMEMURA, Ken ANDOH, Toshiro |
| description | Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F380B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 μM and 16 μM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 μM. |
| doi_str_mv | 10.1248/bpb.23.511 |
| format | Article |
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| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2000/04/01, Vol.23(4), pp.511-512 |
| issn | 0918-6158 1347-5215 |
| language | eng |
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| source | MEDLINE; J-STAGE日本語サイト (Free Access); Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Antineoplastic agents Biological and medical sciences dihydroxanthone Enzyme Inhibitors - pharmacology F390B F390C General aspects Humans Medical sciences nidulalin A Pharmacology. Drug treatments Recombinant Proteins - antagonists & inhibitors Topoisomerase I Inhibitors Topoisomerase II Inhibitors topoisomerase inhibitor Xanthines - pharmacology |
| title | Inhibition of DNA Topoisomerases by Nidulalin A Derivatives |
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