Inhibition of DNA Topoisomerases by Nidulalin A Derivatives

Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F380B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 μM and 16 μM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2000/04/01, Vol.23(4), pp.511-512
Hauptverfasser:	SATO, Seiichi, FUKUDA, Yumiko, NAKAGAWA, Ryusuke, TSUJI, Takashi, UMEMURA, Ken, ANDOH, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences dihydroxanthone Enzyme Inhibitors - pharmacology F390B F390C General aspects Humans Medical sciences nidulalin A Pharmacology. Drug treatments Recombinant Proteins - antagonists & inhibitors Topoisomerase I Inhibitors Topoisomerase II Inhibitors topoisomerase inhibitor Xanthines - pharmacology
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Beschreibung
Zusammenfassung:	Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F380B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 μM and 16 μM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 μM.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.23.511