Smooth muscle cell depletion and collagen types in progeric arteries

Review of two autopsy cases of progeria confirms severe smooth muscle cell (SMC) depletion in the atherosclerotic aortic media and the presence of collagen types I, III, IV, V, and VI in the aorta and renal vessels as is consistent with atherosclerotic disease.

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Bibliographische Detailangaben
Veröffentlicht in:	Cardiovascular pathology 2001-05, Vol.10 (3), p.133-136
Hauptverfasser:	Stehbens, William E., Delahunt, Brett, Shozawa, Takeshi, Gilbert-Barness, Enid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aorta - metabolism Aorta - pathology Arteriosclerosis - etiology Arteriosclerosis - metabolism Arteriosclerosis - pathology Atherosclerotic aortic media Blood Vessels - metabolism Blood Vessels - pathology Child Collagen - classification Collagen - metabolism Fatal Outcome Female Humans Male Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Progeria Progeria - complications Progeria - metabolism Progeria - pathology Reference Values Renal Circulation Smooth muscle cell depletion
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Beschreibung
Zusammenfassung:	Review of two autopsy cases of progeria confirms severe smooth muscle cell (SMC) depletion in the atherosclerotic aortic media and the presence of collagen types I, III, IV, V, and VI in the aorta and renal vessels as is consistent with atherosclerotic disease.
ISSN:	1054-8807 1879-1336
DOI:	10.1016/S1054-8807(01)00069-2