TPU-0031-A and B, New Antibiotics of the Novobiocin Group Produced by Streptomyces sp. TP-A0556

Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectros...

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Veröffentlicht in:	Journal of antibiotics 2001/05/25, Vol.54(5), pp.441-447
Hauptverfasser:	SASAKI, TOMOMITSU, IGARASHI, YASUHIRO, SAITO, NORIKO, FURUMAI, TAMOTSU
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Fermentation Fundamental and applied biological sciences. Psychology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Microbiology Microscopy, Electron, Scanning Novobiocin - analogs & derivatives Novobiocin - chemistry Novobiocin - isolation & purification Novobiocin - pharmacology Plant Stems - microbiology Streptomyces - chemistry Streptomyces - metabolism Streptomyces - ultrastructure
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Beschreibung
Zusammenfassung:	Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7'-demethylnovobiocin and 5′′-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.54.441