An Expeditious Approach toward the Total Synthesis of CP-263,114

An Expeditious Approach toward the Total Synthesis of CP-263,114

Assembly of the carbocyclic core of CP-263,114 has been accomplished efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels−Alder sequence, tandem radical cyclization, and the late-stage fragmentation of a densely functionalized isotwistane skeleton.

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Veröffentlicht in:Organic letters 2001-08, Vol.3 (16), p.2435-2438
Hauptverfasser: Njardarson, Jón T, McDonald, Ivar M, Spiegel, David A, Inoue, Munenori, Wood, John L
Format: Artikel
Sprache:eng
Schlagworte:
Cyclization
Enzyme Inhibitors - chemical synthesis
Indicators and Reagents
Maleic Anhydrides - chemical synthesis
Models, Molecular
Oxidation-Reduction
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Zusammenfassung:Assembly of the carbocyclic core of CP-263,114 has been accomplished efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels−Alder sequence, tandem radical cyclization, and the late-stage fragmentation of a densely functionalized isotwistane skeleton.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol015979n