Importance of the host genetic background on immune responses to Helicobacter pylori infection and therapeutic vaccine efficacy

Abstract In order to investigate the role of host factors in Helicobacter pylori infection and immunity, two different strains of inbred mice, C57BL/6 and BALB/c, were infected with a standard H. pylori strain, SS1. A month later, infected mice were immunized orally with whole-cell lysates of H. pyl...

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Veröffentlicht in:	FEMS immunology and medical microbiology 2001-07, Vol.31 (1), p.41-46
Hauptverfasser:	Kim, Jang-Seong, Chang, Ji-Hoon, Chung, Soo-Il, Yum, Jung-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Administration, Oral Animal model Animals Antibodies Antibodies, Bacterial - analysis Antigens, Bacterial - therapeutic use Bacterial Vaccines - therapeutic use Cell culture Cholera Cholera toxin Colonization Colony Count, Microbial Density Disease Models, Animal Female Gastric Mucosa - microbiology Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - genetics Gastrointestinal Diseases - microbiology Helicobacter Infections - drug therapy Helicobacter Infections - genetics Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - immunology Helicobacter pylori - isolation & purification Helicobacter pylori vaccine Host factor Immune response Immunization Immunoglobulin A, Secretory - analysis Immunoglobulin G - analysis Immunotherapy, Active Inbreeding Infections Inoculation Lysates Mice Mice, Inbred BALB C Mice, Inbred C57BL Pathogens Species Specificity Specific Pathogen-Free Organisms Time Factors Toxins Vaccine efficacy Waterborne diseases
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