Comparison of pig, human and rat hepatocytes as a source of liver specific metabolic functions in culture systems--implications for use in bioartificial liver devices

The limited availability of human hepatocytes results in the use of animal cells in most bioartificial liver support devices. In the present work, clinically relevant liver specific metabolic activities were compared in rat, pig and human hepatocytes cultured on liver-derived biomatrix to optimize t...

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Veröffentlicht in:	International journal of artificial organs 2001-06, Vol.24 (6), p.392-396
Hauptverfasser:	Vilei, M T, Granato, A, Ferraresso, C, Neri, D, Carraro, P, Gerunda, G, Muraca, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bilirubin - metabolism Cells, Cultured Diazepam - metabolism Humans Liver - cytology Liver - metabolism Liver, Artificial Male Rats Statistics, Nonparametric Swine Urea - metabolism
Online-Zugang:	Volltext
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