Mutations of the hSNF5/INI1 Gene in Renal Rhabdoid Tumors With Second Primary Brain Tumors

About 10%-15% of rhabdoid tumors of the kidney in young infants are associated with separate primary tumors of the central nervous system. Demographic and outcome data from studies of the hSNF5/INI1 gene in four patients with rhabdoid tumors are presented to help clarify the role of this gene in pre...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2000-04, Vol.92 (8), p.648-650
Hauptverfasser:	Savla, Jayshree, Chen, Tina T.-Y., Schneider, Nancy R., Timmons, Charles F., Delattre, Olivier, Tomlinson, Gail E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Babies Biological and medical sciences Brain Brain Neoplasms - genetics Child, Preschool Chromosomal Proteins, Non-Histone DNA-Binding Proteins - genetics Genes hSNF5/INI1 gene Humans Infant Kidney Neoplasms - genetics Kidneys Male Medical sciences Mutation Neoplasms, Second Primary Nephrology. Urinary tract diseases Rhabdoid Tumor - genetics rhabdoid tumors SMARCB1 Protein Transcription Factors Tumors Tumors of the urinary system
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Beschreibung
Zusammenfassung:	About 10%-15% of rhabdoid tumors of the kidney in young infants are associated with separate primary tumors of the central nervous system. Demographic and outcome data from studies of the hSNF5/INI1 gene in four patients with rhabdoid tumors are presented to help clarify the role of this gene in predisposition to these rare tumor types.
ISSN:	0027-8874 1460-2105
DOI:	10.1093/jnci/92.8.648