Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa

Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC5...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2000-04, Vol.10 (8), p.759-762
Hauptverfasser: CHAVEZ, H, RODRIGUEZ, G, ESTEVEZ-BRAUN, A, RAVELO, A. G, ESTEVEZ-REYES, R, GONZALEZ, A. G, FDEZ-PUENTE, J. L, GARCIA-GRAVALOS, D
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
General pharmacology
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Spectrum Analysis
Triterpenes - chemistry
Triterpenes - isolation & purification
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Zusammenfassung:Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 microM.
ISSN:0960-894X
1464-3405
DOI:10.1016/s0960-894x(00)00082-2