Haptoglobin Polymorphism in Human Immunodeficiency Virus Infection: Hp0 Phenotype Limits Depletion of CD4 Cell Counts in HIV-1—Seropositive Individuals

Patients seropositive for human immunodeficiency virus (HIV) type 1 and seronegative control subjects were categorized by their haptoglobin phenotypes, which were determined by electrophoresis of hemoglobin-supplemented plasma samples followed by benzidine staining. The CD4 cell counts, determined b...

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Veröffentlicht in:	The Journal of infectious diseases 2000-04, Vol.181 (4), p.1483-1485
Hauptverfasser:	Quaye, Isaac K. E., Brandful, Jim, Ekuban, Fred A., Gyan, Ben, Ankrah, Nii-Ayi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS AIDS/HIV Alleles Biological and medical sciences Blood plasma CD4 antigen CD4 Lymphocyte Count Concise Communications Disease transmission Female haptoglobin Haptoglobins - genetics HIV HIV 1 HIV infections HIV Infections - genetics HIV Infections - immunology Human immunodeficiency virus 1 Human viral diseases Humans Infections Infectious diseases Male Medical sciences Phenotype Phenotypes Polymorphism, Genetic Prognosis Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	Patients seropositive for human immunodeficiency virus (HIV) type 1 and seronegative control subjects were categorized by their haptoglobin phenotypes, which were determined by electrophoresis of hemoglobin-supplemented plasma samples followed by benzidine staining. The CD4 cell counts, determined by flow cytometry from peripheral blood mononuclear cells according to subject categories, were severely diminished in seropositive patients with the Hp2-2 phenotype (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/315377