High-Performance Liquid Chromatography—Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the leaves and Fruits of the Ginkgo Tree (Ginkgo biloba)
A method is developed for qualitative analysis of ginkgolic acids in the leaves and fruits of Ginkgo biloba by high-performance liquid chromatography (HPLC)-electrospray ionization-mass spectrometry technique. Negative ionization mode is successful in obtaining a very abundant deprotonated molecule...
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| Veröffentlicht in: | Journal of chromatographic science 2000-04, Vol.38 (4), p.169-173 |
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| container_end_page | 173 |
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| container_issue | 4 |
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| container_title | Journal of chromatographic science |
| container_volume | 38 |
| creator | He, Xian-guo Bernart, Matthew W. Nolan, Gary S. Lin, Long-ze Lindenmaier, Michael P. |
| description | A method is developed for qualitative analysis of ginkgolic acids in the leaves and fruits of Ginkgo biloba by high-performance liquid chromatography (HPLC)-electrospray ionization-mass spectrometry technique. Negative ionization mode is successful in obtaining a very abundant deprotonated molecule [M - H]-. The mass detection sensitivity is higher than ultraviolet detection but relies heavily on the concentration of acetic acid in the HPLC eluent, which consists of acetonitrile-water-acetic acid. The method is also very specific for the analysis of ginkgolic acid with no interferences from the sample matrix. |
| doi_str_mv | 10.1093/chromsci/38.4.169 |
| format | Article |
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Drug treatments ; Plant Extracts - analysis ; Plant Leaves - chemistry ; Plants, Medicinal ; Salicylates - analysis ; Sensitivity and Specificity</subject><ispartof>Journal of chromatographic science, 2000-04, Vol.38 (4), p.169-173</ispartof><rights>2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-3166c617f32f74dc9d69d51213960fd3758b392df236270857ce61ef79a70d523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1320438$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10766484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Xian-guo</creatorcontrib><creatorcontrib>Bernart, Matthew W.</creatorcontrib><creatorcontrib>Nolan, Gary S.</creatorcontrib><creatorcontrib>Lin, Long-ze</creatorcontrib><creatorcontrib>Lindenmaier, Michael P.</creatorcontrib><title>High-Performance Liquid Chromatography—Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the leaves and Fruits of the Ginkgo Tree (Ginkgo biloba)</title><title>Journal of chromatographic science</title><addtitle>Journal of Chromatographic Science</addtitle><addtitle>Journal of Chromatographic Science</addtitle><description>A method is developed for qualitative analysis of ginkgolic acids in the leaves and fruits of Ginkgo biloba by high-performance liquid chromatography (HPLC)-electrospray ionization-mass spectrometry technique. Negative ionization mode is successful in obtaining a very abundant deprotonated molecule [M - H]-. The mass detection sensitivity is higher than ultraviolet detection but relies heavily on the concentration of acetic acid in the HPLC eluent, which consists of acetonitrile-water-acetic acid. The method is also very specific for the analysis of ginkgolic acid with no interferences from the sample matrix.</description><subject>Acetic Acid - chemistry</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Fruit - chemistry</subject><subject>General pharmacology</subject><subject>Ginkgo biloba - chemistry</subject><subject>Mass Spectrometry - methods</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - analysis</topic><topic>Plant Leaves - chemistry</topic><topic>Plants, Medicinal</topic><topic>Salicylates - analysis</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Xian-guo</creatorcontrib><creatorcontrib>Bernart, Matthew W.</creatorcontrib><creatorcontrib>Nolan, Gary S.</creatorcontrib><creatorcontrib>Lin, Long-ze</creatorcontrib><creatorcontrib>Lindenmaier, Michael P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatographic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Xian-guo</au><au>Bernart, Matthew W.</au><au>Nolan, Gary S.</au><au>Lin, Long-ze</au><au>Lindenmaier, Michael P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Performance Liquid Chromatography—Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the leaves and Fruits of the Ginkgo Tree (Ginkgo biloba)</atitle><jtitle>Journal of chromatographic science</jtitle><stitle>Journal of Chromatographic Science</stitle><addtitle>Journal of Chromatographic Science</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>38</volume><issue>4</issue><spage>169</spage><epage>173</epage><pages>169-173</pages><issn>0021-9665</issn><eissn>1945-239X</eissn><coden>JCHSBZ</coden><abstract>A method is developed for qualitative analysis of ginkgolic acids in the leaves and fruits of Ginkgo biloba by high-performance liquid chromatography (HPLC)-electrospray ionization-mass spectrometry technique. Negative ionization mode is successful in obtaining a very abundant deprotonated molecule [M - H]-. The mass detection sensitivity is higher than ultraviolet detection but relies heavily on the concentration of acetic acid in the HPLC eluent, which consists of acetonitrile-water-acetic acid. The method is also very specific for the analysis of ginkgolic acid with no interferences from the sample matrix.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>10766484</pmid><doi>10.1093/chromsci/38.4.169</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of chromatographic science, 2000-04, Vol.38 (4), p.169-173 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Acetic Acid - chemistry Biological and medical sciences Chromatography, High Pressure Liquid - methods Fruit - chemistry General pharmacology Ginkgo biloba - chemistry Mass Spectrometry - methods Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - analysis Plant Leaves - chemistry Plants, Medicinal Salicylates - analysis Sensitivity and Specificity |
| title | High-Performance Liquid Chromatography—Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the leaves and Fruits of the Ginkgo Tree (Ginkgo biloba) |
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