High-Performance Liquid Chromatography—Electrospray Ionization-Mass Spectrometry Study of Ginkgolic Acid in the leaves and Fruits of the Ginkgo Tree (Ginkgo biloba)

A method is developed for qualitative analysis of ginkgolic acids in the leaves and fruits of Ginkgo biloba by high-performance liquid chromatography (HPLC)-electrospray ionization-mass spectrometry technique. Negative ionization mode is successful in obtaining a very abundant deprotonated molecule...

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Veröffentlicht in:	Journal of chromatographic science 2000-04, Vol.38 (4), p.169-173
Hauptverfasser:	He, Xian-guo, Bernart, Matthew W., Nolan, Gary S., Lin, Long-ze, Lindenmaier, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid - chemistry Biological and medical sciences Chromatography, High Pressure Liquid - methods Fruit - chemistry General pharmacology Ginkgo biloba - chemistry Mass Spectrometry - methods Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - analysis Plant Leaves - chemistry Plants, Medicinal Salicylates - analysis Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	A method is developed for qualitative analysis of ginkgolic acids in the leaves and fruits of Ginkgo biloba by high-performance liquid chromatography (HPLC)-electrospray ionization-mass spectrometry technique. Negative ionization mode is successful in obtaining a very abundant deprotonated molecule [M - H]-. The mass detection sensitivity is higher than ultraviolet detection but relies heavily on the concentration of acetic acid in the HPLC eluent, which consists of acetonitrile-water-acetic acid. The method is also very specific for the analysis of ginkgolic acid with no interferences from the sample matrix.
ISSN:	0021-9665 1945-239X
DOI:	10.1093/chromsci/38.4.169