Ligand density determines the efficiency of negative selection in the thymus

To study the influence of antigen density on the efficiency of negative selection in the thymus, MHC class I (H-2K(b), K(b)) transgenic mice were generated, which expressed a K(b) transgene under the control of its natural promoter at 33% (K(b-lo)) or 150% (K(b-hi)) the surface density of Kb in C57B...

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Veröffentlicht in:	Transplantation 2001-07, Vol.72 (2), p.305-311
Hauptverfasser:	RÖMERMANN, Dorothee, HEATH, William R, ALLISON, Janette, BAYER, Bettina, SORGE, Yanina, MILLER, Jacques F. A. P, HOFFMANN, Matthias W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, T-Lymphocyte - analysis Biological and medical sciences CD4 Antigens - analysis CD8 Antigens - analysis Crosses, Genetic General and cellular metabolism. Vitamins Graft Survival - immunology Graft vs Host Disease - immunology H-2 Antigens - genetics H-2 Antigens - immunology histocompatibility antigen H-2 Ligands Lymph Nodes - immunology Medical sciences Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred Strains Mice, Transgenic Pharmacology. Drug treatments Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Skin Transplantation - immunology T-Lymphocytes - immunology Thymus Gland - immunology Time Factors
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