The Significance of Mast Cells Associated with Basal Cell Carcinoma
In the stroma of basal cell carcinoma (BCC), the numbers of mast cells are increased, but their significance remains unknown. In a retrospective histological study of 74 cases, we investigated the significance of mast cells related to BCC and the possible relationship between increased numbers of ma...
Gespeichert in:
| Veröffentlicht in: | Journal of dermatology 2001-06, Vol.28 (6), p.312-315 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 315 |
|---|---|
| container_issue | 6 |
| container_start_page | 312 |
| container_title | Journal of dermatology |
| container_volume | 28 |
| creator | Erkilic, Suna Erbagci, Zuelal |
| description | In the stroma of basal cell carcinoma (BCC), the numbers of mast cells are increased, but their significance remains unknown. In a retrospective histological study of 74 cases, we investigated the significance of mast cells related to BCC and the possible relationship between increased numbers of mast cells and clinical and histological parameters including the patients' age, sex, subtype of BCC, and severity of peritumoral inflammation. We found a significant increase in peritumoral mast cell numbers over those in uninvolved skin (p |
| doi_str_mv | 10.1111/j.1346-8138.2001.tb00139.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71043422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71043422</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4589-69fb1cb4b9039ebf7fc35d82875326bd195386c118a93c9b617ba4c9e4c473303</originalsourceid><addsrcrecordid>eNqVkDtPwzAQgC0EoqXwF1DEgFgSfLGT2EyUUF4qYqDMlu041FXalDhV239P0kawIeHhfNJ999CH0AXgAJp3PQuA0NhnQFgQYgxBrZpIeLA5QP2f0iHqY8IiP6Q46aET52YYhzwCfIx6ADSJAfM-SidT473bz4XNrZYLbbwy916lq73UFIXzhs6V2sraZN7a1lPvTjpZ7GpeKittF-VcnqKjXBbOnHX_AH08jCbpkz9-e3xOh2Nf04hxP-a5Aq2o4phwo_Ik1yTKWMiSiISxyoBHhMUagElONFcxJEpSzQ3VNCEEkwG63M9dVuXXyrhazK3TzSlyYcqVEwlgSmgYNuDVnyBEccyakxppA3SzR3VVOleZXCwrO5fVVgAWrW0xE61S0SoVrW3R2Rabpvm827NSc5P9tnZ6G-B2D6xtYbb_GC1e7ke7lHwDJ_ONOQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1566858901</pqid></control><display><type>article</type><title>The Significance of Mast Cells Associated with Basal Cell Carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Erkilic, Suna ; Erbagci, Zuelal</creator><creatorcontrib>Erkilic, Suna ; Erbagci, Zuelal</creatorcontrib><description>In the stroma of basal cell carcinoma (BCC), the numbers of mast cells are increased, but their significance remains unknown. In a retrospective histological study of 74 cases, we investigated the significance of mast cells related to BCC and the possible relationship between increased numbers of mast cells and clinical and histological parameters including the patients' age, sex, subtype of BCC, and severity of peritumoral inflammation. We found a significant increase in peritumoral mast cell numbers over those in uninvolved skin (p<0.0001). Morpheaform BCCs had significantly more mast cells than did the other variants (p=0.047). No significant relationship was found between mast cell number and the degree of peritumoral inflammation, patient age, or gender. Our results support previous reports indicating that mast cell numbers are increased in BCC, particularly in its morphoeic variant, implying a contributory role for mast cells in the aggressiveness of BCC.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/j.1346-8138.2001.tb00139.x</identifier><identifier>PMID: 11476109</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; age ; Aged ; Aged, 80 and over ; basal cell carcinoma ; Carcinoma, Basal Cell - pathology ; Female ; Humans ; Male ; mast cells ; Mast Cells - pathology ; Middle Aged ; morpheaform ; Retrospective Studies ; Severity of Illness Index ; sex ; Skin Neoplasms - pathology</subject><ispartof>Journal of dermatology, 2001-06, Vol.28 (6), p.312-315</ispartof><rights>2001 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4589-69fb1cb4b9039ebf7fc35d82875326bd195386c118a93c9b617ba4c9e4c473303</citedby><cites>FETCH-LOGICAL-c4589-69fb1cb4b9039ebf7fc35d82875326bd195386c118a93c9b617ba4c9e4c473303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1346-8138.2001.tb00139.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1346-8138.2001.tb00139.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11476109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erkilic, Suna</creatorcontrib><creatorcontrib>Erbagci, Zuelal</creatorcontrib><title>The Significance of Mast Cells Associated with Basal Cell Carcinoma</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>In the stroma of basal cell carcinoma (BCC), the numbers of mast cells are increased, but their significance remains unknown. In a retrospective histological study of 74 cases, we investigated the significance of mast cells related to BCC and the possible relationship between increased numbers of mast cells and clinical and histological parameters including the patients' age, sex, subtype of BCC, and severity of peritumoral inflammation. We found a significant increase in peritumoral mast cell numbers over those in uninvolved skin (p<0.0001). Morpheaform BCCs had significantly more mast cells than did the other variants (p=0.047). No significant relationship was found between mast cell number and the degree of peritumoral inflammation, patient age, or gender. Our results support previous reports indicating that mast cell numbers are increased in BCC, particularly in its morphoeic variant, implying a contributory role for mast cells in the aggressiveness of BCC.</description><subject>Adult</subject><subject>age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>basal cell carcinoma</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>mast cells</subject><subject>Mast Cells - pathology</subject><subject>Middle Aged</subject><subject>morpheaform</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>sex</subject><subject>Skin Neoplasms - pathology</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkDtPwzAQgC0EoqXwF1DEgFgSfLGT2EyUUF4qYqDMlu041FXalDhV239P0kawIeHhfNJ999CH0AXgAJp3PQuA0NhnQFgQYgxBrZpIeLA5QP2f0iHqY8IiP6Q46aET52YYhzwCfIx6ADSJAfM-SidT473bz4XNrZYLbbwy916lq73UFIXzhs6V2sraZN7a1lPvTjpZ7GpeKittF-VcnqKjXBbOnHX_AH08jCbpkz9-e3xOh2Nf04hxP-a5Aq2o4phwo_Ik1yTKWMiSiISxyoBHhMUagElONFcxJEpSzQ3VNCEEkwG63M9dVuXXyrhazK3TzSlyYcqVEwlgSmgYNuDVnyBEccyakxppA3SzR3VVOleZXCwrO5fVVgAWrW0xE61S0SoVrW3R2Rabpvm827NSc5P9tnZ6G-B2D6xtYbb_GC1e7ke7lHwDJ_ONOQ</recordid><startdate>200106</startdate><enddate>200106</enddate><creator>Erkilic, Suna</creator><creator>Erbagci, Zuelal</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200106</creationdate><title>The Significance of Mast Cells Associated with Basal Cell Carcinoma</title><author>Erkilic, Suna ; Erbagci, Zuelal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4589-69fb1cb4b9039ebf7fc35d82875326bd195386c118a93c9b617ba4c9e4c473303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>basal cell carcinoma</topic><topic>Carcinoma, Basal Cell - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>mast cells</topic><topic>Mast Cells - pathology</topic><topic>Middle Aged</topic><topic>morpheaform</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>sex</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erkilic, Suna</creatorcontrib><creatorcontrib>Erbagci, Zuelal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erkilic, Suna</au><au>Erbagci, Zuelal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Significance of Mast Cells Associated with Basal Cell Carcinoma</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2001-06</date><risdate>2001</risdate><volume>28</volume><issue>6</issue><spage>312</spage><epage>315</epage><pages>312-315</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>In the stroma of basal cell carcinoma (BCC), the numbers of mast cells are increased, but their significance remains unknown. In a retrospective histological study of 74 cases, we investigated the significance of mast cells related to BCC and the possible relationship between increased numbers of mast cells and clinical and histological parameters including the patients' age, sex, subtype of BCC, and severity of peritumoral inflammation. We found a significant increase in peritumoral mast cell numbers over those in uninvolved skin (p<0.0001). Morpheaform BCCs had significantly more mast cells than did the other variants (p=0.047). No significant relationship was found between mast cell number and the degree of peritumoral inflammation, patient age, or gender. Our results support previous reports indicating that mast cell numbers are increased in BCC, particularly in its morphoeic variant, implying a contributory role for mast cells in the aggressiveness of BCC.</abstract><cop>England</cop><pmid>11476109</pmid><doi>10.1111/j.1346-8138.2001.tb00139.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-2407 |
| ispartof | Journal of dermatology, 2001-06, Vol.28 (6), p.312-315 |
| issn | 0385-2407 1346-8138 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71043422 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult age Aged Aged, 80 and over basal cell carcinoma Carcinoma, Basal Cell - pathology Female Humans Male mast cells Mast Cells - pathology Middle Aged morpheaform Retrospective Studies Severity of Illness Index sex Skin Neoplasms - pathology |
| title | The Significance of Mast Cells Associated with Basal Cell Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T07%3A56%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Significance%20of%20Mast%20Cells%20Associated%20with%20Basal%20Cell%20Carcinoma&rft.jtitle=Journal%20of%20dermatology&rft.au=Erkilic,%20Suna&rft.date=2001-06&rft.volume=28&rft.issue=6&rft.spage=312&rft.epage=315&rft.pages=312-315&rft.issn=0385-2407&rft.eissn=1346-8138&rft_id=info:doi/10.1111/j.1346-8138.2001.tb00139.x&rft_dat=%3Cproquest_cross%3E71043422%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1566858901&rft_id=info:pmid/11476109&rfr_iscdi=true |