Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice

This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and s...

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Veröffentlicht in:	European journal of pharmacology 2000-03, Vol.392 (3), p.147-156
Hauptverfasser:	Hao, Shuzhen, Avraham, Yosefa, Mechoulam, Raphael, Berry, Elliot M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anandamide Animals Arachidonic Acids - pharmacology Behavioral psychophysiology Biological and medical sciences Cannabinoid Receptor Modulators Catecholamine, 5-hydroxytryptamine, serotonin (5-HT) Catecholamines - metabolism Cognition - drug effects Cognition - physiology Cognitive function Corticosterone Corticosterone - metabolism Diet Diet restriction Dose-Response Relationship, Drug Eating - drug effects Endocannabinoids Feeding. Feeding behavior Female Food intake Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Maze Learning - drug effects Mice Mice, Inbred BALB C Neurotransmission and behavior Neurotransmitter Agents - metabolism Polyunsaturated Alkamides Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Serotonin - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	This investigation reports the possible role of the endocannabinoid anandamide on modulating the behavioral and neurochemical consequences of semi-starvation. We studied the effect of very low dose anandamide (0.001 mg/kg) administration on food intake, cognitive function and catecholaminergic and serotonergic pathways in two murine brain areas concerned with appetite (hypothalamus) and learning (hippocampus), and the peripheral corticosterone response to the stress of 40% diet restriction. Anandamide-treated mice consumed 44% more food ( P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/S0014-2999(00)00059-5