Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853
Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens w...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2000-04, Vol.181 (4), p.1486-1490 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1490 |
|---|---|
| container_issue | 4 |
| container_start_page | 1486 |
| container_title | The Journal of infectious diseases |
| container_volume | 181 |
| creator | MacArthur, Rodger D. Lederman, Michael M. Benson, Constance A. Chernoff, Miriam C. MacGregor, Rob Roy Spritzler, John Mahon, Laura F. Yen-Lieberman, Belinda Purvis, Scott |
| description | Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)—6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P |
| doi_str_mv | 10.1086/315370 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_71040378</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30109170</jstor_id><sourcerecordid>30109170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-f06c070e6bc3d93596f28554a3eee3da666c63fa4be9665dd5cd7277c92852843</originalsourceid><addsrcrecordid>eNqFkUGO0zAUhi0EYkqBG4C8QOwCdhzbCbtR6LSVihigjBCbyHVeJM8kdsZORu2OQ3AajsNJSEhVZsfGT9b_6XuWf4SeU_KGklS8ZZQzSR6g2TgjISh7iGaExHFE0yw7Q09CuCaEJEzIx-iMEilinsYz9GtRVaC7gF2FPxy02yndgTd9g9XdeOauaWvY__7xc21H0DiLtx5U14Dt8HDJD527MRbwYt96CGEEjMWrvlEWr5umt66EymgDVh_wlfF9OMmgxJfgg7PhHf4Moa-nd5yv33_BeW2s0aoethlVB7z0rm_xpXed067GKWdP0aNqSODZcc7R14vFNl9Fm4_LdX6-iTTLeBdVRGgiCYidZmXGeCaqOOU8UQwAWKmEEFqwSiU7yITgZcl1KWMpdTZgcZqwOXo9eVvvbnsIXdGYoKGulQXXh0JSkhAm0_-CVKYZS_k9o_YuBA9V0XrTKH8oKCnGOoupzgF8eTT2uwbKe9jU3wC8OgIqDJ9VeWW1Cf-4JOVkUM3Riwm7Dp3zp5gRSjL6d0805SZ0sD_lyt8UQjLJi9W378V2mW-WV_RTsWV_AIUjw6M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17893854</pqid></control><display><type>article</type><title>Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>MacArthur, Rodger D. ; Lederman, Michael M. ; Benson, Constance A. ; Chernoff, Miriam C. ; MacGregor, Rob Roy ; Spritzler, John ; Mahon, Laura F. ; Yen-Lieberman, Belinda ; Purvis, Scott</creator><creatorcontrib>MacArthur, Rodger D. ; Lederman, Michael M. ; Benson, Constance A. ; Chernoff, Miriam C. ; MacGregor, Rob Roy ; Spritzler, John ; Mahon, Laura F. ; Yen-Lieberman, Belinda ; Purvis, Scott</creatorcontrib><description>Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)—6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P<.01) for plasma levels of IL-1β and HIV RNA to decrease at week 8. Nonsignificant decreases in plasma levels of TNF-α, IL-1β, IL-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315370</identifier><identifier>PMID: 10762582</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; AIDS-Related Opportunistic Infections - blood ; AIDS-Related Opportunistic Infections - drug therapy ; AIDS/HIV ; Anti-Bacterial Agents - therapeutic use ; Antiretrovirals ; Antitubercular Agents - therapeutic use ; Bacterial diseases ; Biological and medical sciences ; Blood plasma ; Clarithromycin - therapeutic use ; Concise Communications ; Cytokines ; Cytokines - blood ; Datasets ; Ethambutol - therapeutic use ; HIV ; HIV 1 ; Human bacterial diseases ; Human immunodeficiency virus 1 ; Humans ; Infections ; Infectious diseases ; interleukin 1^b ; interleukin 1b ; Interleukin-1 - blood ; Interleukin-6 - blood ; Medical sciences ; Mycobacterium avium ; Mycobacterium avium complex ; Mycobacterium avium-intracellulare Infection - blood ; Mycobacterium avium-intracellulare Infection - drug therapy ; Pilot Projects ; Rifabutin - therapeutic use ; RNA ; RNA, Viral - analysis ; Tuberculosis and atypical mycobacterial infections ; Tumor Necrosis Factor-alpha - metabolism ; Viral Load</subject><ispartof>The Journal of infectious diseases, 2000-04, Vol.181 (4), p.1486-1490</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-f06c070e6bc3d93596f28554a3eee3da666c63fa4be9665dd5cd7277c92852843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30109170$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30109170$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1485015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10762582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MacArthur, Rodger D.</creatorcontrib><creatorcontrib>Lederman, Michael M.</creatorcontrib><creatorcontrib>Benson, Constance A.</creatorcontrib><creatorcontrib>Chernoff, Miriam C.</creatorcontrib><creatorcontrib>MacGregor, Rob Roy</creatorcontrib><creatorcontrib>Spritzler, John</creatorcontrib><creatorcontrib>Mahon, Laura F.</creatorcontrib><creatorcontrib>Yen-Lieberman, Belinda</creatorcontrib><creatorcontrib>Purvis, Scott</creatorcontrib><title>Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)—6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P<.01) for plasma levels of IL-1β and HIV RNA to decrease at week 8. Nonsignificant decreases in plasma levels of TNF-α, IL-1β, IL-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study.</description><subject>Adult</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - blood</subject><subject>AIDS-Related Opportunistic Infections - drug therapy</subject><subject>AIDS/HIV</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antiretrovirals</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Blood plasma</subject><subject>Clarithromycin - therapeutic use</subject><subject>Concise Communications</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Datasets</subject><subject>Ethambutol - therapeutic use</subject><subject>HIV</subject><subject>HIV 1</subject><subject>Human bacterial diseases</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>interleukin 1^b</subject><subject>interleukin 1b</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Medical sciences</subject><subject>Mycobacterium avium</subject><subject>Mycobacterium avium complex</subject><subject>Mycobacterium avium-intracellulare Infection - blood</subject><subject>Mycobacterium avium-intracellulare Infection - drug therapy</subject><subject>Pilot Projects</subject><subject>Rifabutin - therapeutic use</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Viral Load</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGO0zAUhi0EYkqBG4C8QOwCdhzbCbtR6LSVihigjBCbyHVeJM8kdsZORu2OQ3AajsNJSEhVZsfGT9b_6XuWf4SeU_KGklS8ZZQzSR6g2TgjISh7iGaExHFE0yw7Q09CuCaEJEzIx-iMEilinsYz9GtRVaC7gF2FPxy02yndgTd9g9XdeOauaWvY__7xc21H0DiLtx5U14Dt8HDJD527MRbwYt96CGEEjMWrvlEWr5umt66EymgDVh_wlfF9OMmgxJfgg7PhHf4Moa-nd5yv33_BeW2s0aoethlVB7z0rm_xpXed067GKWdP0aNqSODZcc7R14vFNl9Fm4_LdX6-iTTLeBdVRGgiCYidZmXGeCaqOOU8UQwAWKmEEFqwSiU7yITgZcl1KWMpdTZgcZqwOXo9eVvvbnsIXdGYoKGulQXXh0JSkhAm0_-CVKYZS_k9o_YuBA9V0XrTKH8oKCnGOoupzgF8eTT2uwbKe9jU3wC8OgIqDJ9VeWW1Cf-4JOVkUM3Riwm7Dp3zp5gRSjL6d0805SZ0sD_lyt8UQjLJi9W378V2mW-WV_RTsWV_AIUjw6M</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>MacArthur, Rodger D.</creator><creator>Lederman, Michael M.</creator><creator>Benson, Constance A.</creator><creator>Chernoff, Miriam C.</creator><creator>MacGregor, Rob Roy</creator><creator>Spritzler, John</creator><creator>Mahon, Laura F.</creator><creator>Yen-Lieberman, Belinda</creator><creator>Purvis, Scott</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853</title><author>MacArthur, Rodger D. ; Lederman, Michael M. ; Benson, Constance A. ; Chernoff, Miriam C. ; MacGregor, Rob Roy ; Spritzler, John ; Mahon, Laura F. ; Yen-Lieberman, Belinda ; Purvis, Scott</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-f06c070e6bc3d93596f28554a3eee3da666c63fa4be9665dd5cd7277c92852843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - blood</topic><topic>AIDS-Related Opportunistic Infections - drug therapy</topic><topic>AIDS/HIV</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antiretrovirals</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Blood plasma</topic><topic>Clarithromycin - therapeutic use</topic><topic>Concise Communications</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Datasets</topic><topic>Ethambutol - therapeutic use</topic><topic>HIV</topic><topic>HIV 1</topic><topic>Human bacterial diseases</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>interleukin 1^b</topic><topic>interleukin 1b</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Medical sciences</topic><topic>Mycobacterium avium</topic><topic>Mycobacterium avium complex</topic><topic>Mycobacterium avium-intracellulare Infection - blood</topic><topic>Mycobacterium avium-intracellulare Infection - drug therapy</topic><topic>Pilot Projects</topic><topic>Rifabutin - therapeutic use</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MacArthur, Rodger D.</creatorcontrib><creatorcontrib>Lederman, Michael M.</creatorcontrib><creatorcontrib>Benson, Constance A.</creatorcontrib><creatorcontrib>Chernoff, Miriam C.</creatorcontrib><creatorcontrib>MacGregor, Rob Roy</creatorcontrib><creatorcontrib>Spritzler, John</creatorcontrib><creatorcontrib>Mahon, Laura F.</creatorcontrib><creatorcontrib>Yen-Lieberman, Belinda</creatorcontrib><creatorcontrib>Purvis, Scott</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MacArthur, Rodger D.</au><au>Lederman, Michael M.</au><au>Benson, Constance A.</au><au>Chernoff, Miriam C.</au><au>MacGregor, Rob Roy</au><au>Spritzler, John</au><au>Mahon, Laura F.</au><au>Yen-Lieberman, Belinda</au><au>Purvis, Scott</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>181</volume><issue>4</issue><spage>1486</spage><epage>1490</epage><pages>1486-1490</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)—6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P<.01) for plasma levels of IL-1β and HIV RNA to decrease at week 8. Nonsignificant decreases in plasma levels of TNF-α, IL-1β, IL-6, and HIV RNA were also seen in those individuals who remained on stable antiretroviral therapy throughout the 8 weeks of the study.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10762582</pmid><doi>10.1086/315370</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2000-04, Vol.181 (4), p.1486-1490 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71040378 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult AIDS AIDS-Related Opportunistic Infections - blood AIDS-Related Opportunistic Infections - drug therapy AIDS/HIV Anti-Bacterial Agents - therapeutic use Antiretrovirals Antitubercular Agents - therapeutic use Bacterial diseases Biological and medical sciences Blood plasma Clarithromycin - therapeutic use Concise Communications Cytokines Cytokines - blood Datasets Ethambutol - therapeutic use HIV HIV 1 Human bacterial diseases Human immunodeficiency virus 1 Humans Infections Infectious diseases interleukin 1^b interleukin 1b Interleukin-1 - blood Interleukin-6 - blood Medical sciences Mycobacterium avium Mycobacterium avium complex Mycobacterium avium-intracellulare Infection - blood Mycobacterium avium-intracellulare Infection - drug therapy Pilot Projects Rifabutin - therapeutic use RNA RNA, Viral - analysis Tuberculosis and atypical mycobacterial infections Tumor Necrosis Factor-alpha - metabolism Viral Load |
| title | Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T09%3A34%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Mycobacterium%20avium%20Complex%E2%80%94Infection%20Treatment%20on%20Cytokine%20Expression%20in%20Human%20Immunodeficiency%20Virus%E2%80%94Infected%20Persons:%20Results%20of%20AIDS%20Clinical%20Trials%20Group%20Protocol%20853&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=MacArthur,%20Rodger%20D.&rft.date=2000-04-01&rft.volume=181&rft.issue=4&rft.spage=1486&rft.epage=1490&rft.pages=1486-1490&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/315370&rft_dat=%3Cjstor_proqu%3E30109170%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17893854&rft_id=info:pmid/10762582&rft_jstor_id=30109170&rfr_iscdi=true |