Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853
Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens w...
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Veröffentlicht in: | The Journal of infectious diseases 2000-04, Vol.181 (4), p.1486-1490 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)—6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P |
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ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1086/315370 |