Effects of Mycobacterium avium Complex—Infection Treatment on Cytokine Expression in Human Immunodeficiency Virus—Infected Persons: Results of AIDS Clinical Trials Group Protocol 853

Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens w...

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Veröffentlicht in:The Journal of infectious diseases 2000-04, Vol.181 (4), p.1486-1490
Hauptverfasser: MacArthur, Rodger D., Lederman, Michael M., Benson, Constance A., Chernoff, Miriam C., MacGregor, Rob Roy, Spritzler, John, Mahon, Laura F., Yen-Lieberman, Belinda, Purvis, Scott
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Sprache:eng
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Zusammenfassung:Human immunodeficiency virus (HIV) type 1—infected persons with newly diagnosed Mycobacterium avium complex (MAC) bacteremia were enrolled in an 8-week study to determine whether treatment of MAC infection is associated with decreases in plasma tumor necrosis factor (TNF)-α levels. Blood specimens were obtained for quantitative MAC cultures and to determine plasma levels of HIV RNA, TNF-α, and other proinflammatory cytokines. MAC levels decreased by 1.75 log at week 4 (P = .008) and by 2.48 log at week 8 (P = .001). Plasma TNF-α decreased by 0.15 log at week 4 (P = .042) and by 0.40 log at week 8 (P = .027). Plasma interleukin (IL)—6 decreased by 0.56 log at week 8 (P = .039). There were nonsignificant trends (P
ISSN:0022-1899
1537-6613
DOI:10.1086/315370