Pretreatment characteristics and clinical outcome of acute promyelocytic leukaemia patients according to the PML‐RARα isoforms: a study of the PETHEMA group

Of 167 newly diagnosed acute promyelocytic leukaemia patients, 83 patients were long (L)‐form (50%), eight variable (V)‐form (5%) and 76 short (S)‐form (45%). The V‐form and S‐form groups presented a significantly higher percentage of patients with white blood cell counts > 10 × 109/l (P ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of haematology 2001-07, Vol.114 (1), p.99-103
Hauptverfasser:	González, M., Barragán, E., Bolufer, P., Chillón, C., Colomer, D., Borstein, R., Calasanz, M. J., Gómez‐Casares, M. T., Villegas, A., Marugán, I., Román, J., Martín, G., Rayón, C., Debén, G., Tormo, M., Díaz‐Mediavilla, J., Esteve, J., González‐San Miguel, J., Rivas, C., Pérez‐Equiza, K., García‐Sanz, R., Capote, F. J., Ribera, J. M., Arias, J., León, A., Sanz, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute promyelocytic leukaemia Adolescent Adult Aged all‐trans retinoic acid (ATRA) Antigens, CD34 - analysis Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Child Child, Preschool clinical outcome complete remission Disease-Free Survival Female Hematologic and hematopoietic diseases Humans Infant Infant, Newborn Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - immunology Leukemia, Promyelocytic, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Male Medical sciences Middle Aged Neoplasm Proteins - genetics Oncogene Proteins, Fusion - genetics PML/RARα isoform Polymerase Chain Reaction - methods Prognosis Proportional Hazards Models Protein Isoforms - genetics reverse transcription–polymerase chain reaction (RT–PCR) Treatment Outcome Tretinoin - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Of 167 newly diagnosed acute promyelocytic leukaemia patients, 83 patients were long (L)‐form (50%), eight variable (V)‐form (5%) and 76 short (S)‐form (45%). The V‐form and S‐form groups presented a significantly higher percentage of patients with white blood cell counts > 10 × 109/l (P
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.2001.02915.x