Sinus disease in cystic fibrosis

Sinus abnormalities are prevalent in patients with CF. Symptoms such as nasal obstruction, loss of taste, and chronic headaches are common and often difficult to treat. When evaluating a patient with chronic sinusitis, the findings of noneosinophilic nasal polyps, unusual bacterial organisms, or specific radiographic features suggest the underlying diagnosis of CF. CF should be looked for even in the absence of pulmonary or gastrointestinal symptoms (34). Medical and surgical therapy reduces morbidity in CF patients, although much remains unknown about ideal therapeutic management.[PUBLICATION ABSTRACT]