Prunioside A:  A New Terpene Glycoside from Spiraea prunifolia

Prunioside A:  A New Terpene Glycoside from Spiraea prunifolia

Prunioside A (1) has been isolated from an EtOAc-soluble extract of Spiraea prunifolia var. simpliciflora by a combination of chromatographic techniques. The structure was determined primarily by extensive NMR experiments. Compound 1 is a unique terpene glycoside. Its acetylated derivative (1a) inhi...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2001-07, Vol.64 (7), p.942-944
Hauptverfasser: OH, Hyuncheol, OH, Gi-Su, SEO, Won-Gil, PAE, Hyun-Ock, CHAI, Kyu-Yun, KWON, Tae-Oh, LEE, Young-Hang, CHUNG, Hun-Taeg, LEE, Ho-Sub
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Cells, Cultured - drug effects
Cells, Cultured - metabolism
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
General pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Korea
Macrophages - drug effects
Macrophages - metabolism
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Molecular Structure
Nitric Oxide - biosynthesis
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase - biosynthesis
Nitric Oxide Synthase Type II
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Roots - chemistry
Plants, Medicinal - chemistry
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - pharmacology
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Zusammenfassung:Prunioside A (1) has been isolated from an EtOAc-soluble extract of Spiraea prunifolia var. simpliciflora by a combination of chromatographic techniques. The structure was determined primarily by extensive NMR experiments. Compound 1 is a unique terpene glycoside. Its acetylated derivative (1a) inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells in a dose-dependent manner.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0005513