Focusing-in on microtubules
A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs,...
Gespeichert in:
| Veröffentlicht in: | Current Opinion in Structural Biology 2000-04, Vol.10 (2), p.236-241 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 241 |
|---|---|
| container_issue | 2 |
| container_start_page | 236 |
| container_title | Current Opinion in Structural Biology |
| container_volume | 10 |
| creator | Amos, Linda A |
| description | A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted. |
| doi_str_mv | 10.1016/S0959-440X(00)00070-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71026343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0959440X00000701</els_id><sourcerecordid>71026343</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-85cd0d26fc41581117f00b88fef1b1e73d011fe6547e7ba96b6b521ccce275793</originalsourceid><addsrcrecordid>eNqFkE1Lw0AQhhdRbKz-AlF6Ej1EZ7LZ3eQkUqwKBQ8q9LYkm4ms5KPuJoL_3rQp4s3TXJ533pmHsTOEawSUNy-QijSMY1hdAlwBgIIQ91iAiUpD4Hy1z4JfZMKOvP8YIIlxcsgmCErwBOKAnS5a03vbvIe2mbXNrLbGtV2f9xX5Y3ZQZpWnk92csrfF_ev8MVw-PzzN75ah4RK7MBGmgCKSpYlRJIioSoA8SUoqMUdSvADEkqSIFak8S2UucxGhMYYiJVTKp-xi3Lt27WdPvtO19YaqKmuo7b1WCJHkMR9AMYLDjd47KvXa2Tpz3xpBb6zorRW9eVkD6K0VjUPufFfQ5zUVf1KjhgG4HQEa3vyy5LQ3lhpDhXVkOl209p-KH9Y3cCU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71026343</pqid></control><display><type>article</type><title>Focusing-in on microtubules</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Amos, Linda A</creator><creatorcontrib>Amos, Linda A</creatorcontrib><description>A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.</description><identifier>ISSN: 0959-440X</identifier><identifier>EISSN: 1879-033X</identifier><identifier>DOI: 10.1016/S0959-440X(00)00070-1</identifier><identifier>PMID: 10753804</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cryo-electron microscopy ; Crystallography, X-Ray ; Cytoskeleton - ultrastructure ; Dynein ; Dyneins - chemistry ; FtsZ ; GTP Phosphohydrolases - chemistry ; GTPase ; Humans ; KIF1A ; Kinesin ; Kinesin - chemistry ; Microtubules - chemistry ; Models, Molecular ; Molecular Motor Proteins - chemistry ; Paclitaxel ; Protein Conformation ; Protein Structure, Tertiary ; tau Proteins - chemistry ; tau Proteins - metabolism ; Tubulin ; Tubulin - chemistry ; Tubulin - metabolism</subject><ispartof>Current Opinion in Structural Biology, 2000-04, Vol.10 (2), p.236-241</ispartof><rights>2000 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-85cd0d26fc41581117f00b88fef1b1e73d011fe6547e7ba96b6b521ccce275793</citedby><cites>FETCH-LOGICAL-c361t-85cd0d26fc41581117f00b88fef1b1e73d011fe6547e7ba96b6b521ccce275793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0959-440X(00)00070-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,778,782,790,3539,27905,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10753804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amos, Linda A</creatorcontrib><title>Focusing-in on microtubules</title><title>Current Opinion in Structural Biology</title><addtitle>Curr Opin Struct Biol</addtitle><description>A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.</description><subject>Animals</subject><subject>Cryo-electron microscopy</subject><subject>Crystallography, X-Ray</subject><subject>Cytoskeleton - ultrastructure</subject><subject>Dynein</subject><subject>Dyneins - chemistry</subject><subject>FtsZ</subject><subject>GTP Phosphohydrolases - chemistry</subject><subject>GTPase</subject><subject>Humans</subject><subject>KIF1A</subject><subject>Kinesin</subject><subject>Kinesin - chemistry</subject><subject>Microtubules - chemistry</subject><subject>Models, Molecular</subject><subject>Molecular Motor Proteins - chemistry</subject><subject>Paclitaxel</subject><subject>Protein Conformation</subject><subject>Protein Structure, Tertiary</subject><subject>tau Proteins - chemistry</subject><subject>tau Proteins - metabolism</subject><subject>Tubulin</subject><subject>Tubulin - chemistry</subject><subject>Tubulin - metabolism</subject><issn>0959-440X</issn><issn>1879-033X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbKz-AlF6Ej1EZ7LZ3eQkUqwKBQ8q9LYkm4ms5KPuJoL_3rQp4s3TXJ533pmHsTOEawSUNy-QijSMY1hdAlwBgIIQ91iAiUpD4Hy1z4JfZMKOvP8YIIlxcsgmCErwBOKAnS5a03vbvIe2mbXNrLbGtV2f9xX5Y3ZQZpWnk92csrfF_ev8MVw-PzzN75ah4RK7MBGmgCKSpYlRJIioSoA8SUoqMUdSvADEkqSIFak8S2UucxGhMYYiJVTKp-xi3Lt27WdPvtO19YaqKmuo7b1WCJHkMR9AMYLDjd47KvXa2Tpz3xpBb6zorRW9eVkD6K0VjUPufFfQ5zUVf1KjhgG4HQEa3vyy5LQ3lhpDhXVkOl209p-KH9Y3cCU</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>Amos, Linda A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Focusing-in on microtubules</title><author>Amos, Linda A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-85cd0d26fc41581117f00b88fef1b1e73d011fe6547e7ba96b6b521ccce275793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Cryo-electron microscopy</topic><topic>Crystallography, X-Ray</topic><topic>Cytoskeleton - ultrastructure</topic><topic>Dynein</topic><topic>Dyneins - chemistry</topic><topic>FtsZ</topic><topic>GTP Phosphohydrolases - chemistry</topic><topic>GTPase</topic><topic>Humans</topic><topic>KIF1A</topic><topic>Kinesin</topic><topic>Kinesin - chemistry</topic><topic>Microtubules - chemistry</topic><topic>Models, Molecular</topic><topic>Molecular Motor Proteins - chemistry</topic><topic>Paclitaxel</topic><topic>Protein Conformation</topic><topic>Protein Structure, Tertiary</topic><topic>tau Proteins - chemistry</topic><topic>tau Proteins - metabolism</topic><topic>Tubulin</topic><topic>Tubulin - chemistry</topic><topic>Tubulin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amos, Linda A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Structural Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amos, Linda A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focusing-in on microtubules</atitle><jtitle>Current Opinion in Structural Biology</jtitle><addtitle>Curr Opin Struct Biol</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>10</volume><issue>2</issue><spage>236</spage><epage>241</epage><pages>236-241</pages><issn>0959-440X</issn><eissn>1879-033X</eissn><abstract>A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>10753804</pmid><doi>10.1016/S0959-440X(00)00070-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-440X |
| ispartof | Current Opinion in Structural Biology, 2000-04, Vol.10 (2), p.236-241 |
| issn | 0959-440X 1879-033X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71026343 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Cryo-electron microscopy Crystallography, X-Ray Cytoskeleton - ultrastructure Dynein Dyneins - chemistry FtsZ GTP Phosphohydrolases - chemistry GTPase Humans KIF1A Kinesin Kinesin - chemistry Microtubules - chemistry Models, Molecular Molecular Motor Proteins - chemistry Paclitaxel Protein Conformation Protein Structure, Tertiary tau Proteins - chemistry tau Proteins - metabolism Tubulin Tubulin - chemistry Tubulin - metabolism |
| title | Focusing-in on microtubules |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T10%3A45%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Focusing-in%20on%20microtubules&rft.jtitle=Current%20Opinion%20in%20Structural%20Biology&rft.au=Amos,%20Linda%20A&rft.date=2000-04-01&rft.volume=10&rft.issue=2&rft.spage=236&rft.epage=241&rft.pages=236-241&rft.issn=0959-440X&rft.eissn=1879-033X&rft_id=info:doi/10.1016/S0959-440X(00)00070-1&rft_dat=%3Cproquest_cross%3E71026343%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71026343&rft_id=info:pmid/10753804&rft_els_id=S0959440X00000701&rfr_iscdi=true |