Focusing-in on microtubules

Focusing-in on microtubules

A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs,...

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Veröffentlicht in:Current Opinion in Structural Biology 2000-04, Vol.10 (2), p.236-241
1. Verfasser: Amos, Linda A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cryo-electron microscopy
Crystallography, X-Ray
Cytoskeleton - ultrastructure
Dynein
Dyneins - chemistry
FtsZ
GTP Phosphohydrolases - chemistry
GTPase
Humans
KIF1A
Kinesin
Kinesin - chemistry
Microtubules - chemistry
Models, Molecular
Molecular Motor Proteins - chemistry
Paclitaxel
Protein Conformation
Protein Structure, Tertiary
tau Proteins - chemistry
tau Proteins - metabolism
Tubulin
Tubulin - chemistry
Tubulin - metabolism
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Beschreibung
Zusammenfassung:A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(00)00070-1