Scavenging of Fluorinated N,N ‘-Dialkylureas by Hydrogen Binding:  A Novel Separation Method for Fluorous Synthesis

Scavenging of Fluorinated N,N ‘-Dialkylureas by Hydrogen Binding:  A Novel Separation Method for Fluorous Synthesis

A dramatic solubility increase in fluorous solvents is observed for N,N‘-di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separatio...

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Veröffentlicht in:Organic letters 2001-07, Vol.3 (15), p.2361-2364
Hauptverfasser: Palomo, Claudio, Aizpurua, Jesus M, Loinaz, Iraida, Fernandez-Berridi, Maria Jose, Irusta, Lourdes
Format: Artikel
Sprache:eng
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Esters - isolation & purification
Fluorocarbons - chemistry
Peptides - isolation & purification
Urea - analogs & derivatives
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container_end_page 2364
container_issue 15
container_start_page 2361
container_title Organic letters
container_volume 3
creator Palomo, Claudio
Aizpurua, Jesus M
Loinaz, Iraida
Fernandez-Berridi, Maria Jose
Irusta, Lourdes
description A dramatic solubility increase in fluorous solvents is observed for N,N‘-di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separation method.
doi_str_mv 10.1021/ol016165+
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subjects Esters - isolation & purification
Fluorocarbons - chemistry
Peptides - isolation & purification
Urea - analogs & derivatives
title Scavenging of Fluorinated N,N ‘-Dialkylureas by Hydrogen Binding:  A Novel Separation Method for Fluorous Synthesis
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