Scavenging of Fluorinated N,N ‘-Dialkylureas by Hydrogen Binding: A Novel Separation Method for Fluorous Synthesis

A dramatic solubility increase in fluorous solvents is observed for N,N‘-di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separatio...

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Veröffentlicht in:	Organic letters 2001-07, Vol.3 (15), p.2361-2364
Hauptverfasser:	Palomo, Claudio, Aizpurua, Jesus M, Loinaz, Iraida, Fernandez-Berridi, Maria Jose, Irusta, Lourdes
Format:	Artikel
Sprache:	eng
Schlagworte:	Esters - isolation & purification Fluorocarbons - chemistry Peptides - isolation & purification Urea - analogs & derivatives
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A dramatic solubility increase in fluorous solvents is observed for N,N‘-di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separation method.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol016165+